Brock Purdy was listed as limited for Wednesday's practice by San Francisco 49ers head coach Kyle Shanahan, suggesting some reason for optimism ahead of their Week 13 matchup with the Buffalo Bills. But any positive feeling was soon overshadowed by what Purdy actually did in practice,

The San Francisco 49ers will be without their starting quarterback and their best defensive player when they visit the Green Bay Packers on Sunday.

The stars' value has never been more pronounced, as the 49ers bumbled their way to one of the worst losses in the

On Friday, the Niners announced Bosa would be OUT for their game against the Green Bay Packers. Joining him on the sideline is also quarterback Brock Purdy, who was similarly ruled OUT in Week 12. 49ers rule out QB Brock Purdy and DE Nick Bosa Sunday at Packers pic.twitter.com/ML2HrKCVj4

The San Francisco 49ers are expecting to get star tight end George Kittle back this week for a key game against Green Bay, but are uncertain whether top pass rusher Nick Bosa will be able to play.

This just isn't the 49ers' week. They have now been dealt the worst-case scenario with Nick Bosa's status against the Packers.

Quarterback Brock Purdy is scheduled for limited practice on Wednesday as the 49ers return to work after a disastrous game in Green Bay. Purdy, who sustained a right shoulder injury in the 49ers’ game Nov.

The 49ers are welcoming Brock Purdy back to practice today after shoulder soreness kept him out of Sunday’s loss at Green Bay.