Kickoff from Santiago Bernabeu Stadium in Madrid is set for 3 p.m. ET. The hosts are -500 favorites (risk $500 to win $100) on the 90-minute money line in the latest Real Madrid vs. Osasuna odds, while Osasuna are +950 underdogs.

Madrid have won five of their last six meetings with Osasuna – with four of those victories coming by at least two goals – and won this respective fixture 4-0 last season, while also winning 4-0 at home the season before. In fact, Osasuna’s last win at the Bernabeu was in 2004!