Before you make any Week 13 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen. Cohen, a SportsLine NFL expert and host of the Friday "Early Edge NFL Props Show" on SportsLine's YouTube page,

Not interested in this game? Check out expert picks and best bets for every NFL game this week. Buffalo had its bye and the 49ers are so banged up that it’s tough to back them in this spot — especially cause the Bills are hitting their stride.

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, who are in serious danger of missin

Bills: The Buffalo Bills were off in Week 12, so they didn’t move in our rankings. They are still the clear No. 2 team in the AFC, and you can make an argument that they are No. 1 after beating the Chiefs in Week 11.

The Buffalo Bills had a week off to rest after their victory over the Kansas City Chiefs in Week 11. The bye week came at a great time for Buffalo, riding high after that victory over the Chiefs pushed their win streak to six games.

Even after a week off, the Bills are still considered the second-best team in the NFL, at least according to this week's power rankings.