When Brock Purdy started looking visibly uncomfortable during the fourth quarter of his Week 11 showdown against the Seattle ...

One of the best receivers in the league will be on display when George Kittle and the San Francisco 49ers visit the Buffalo ...

While making updates to the team’s injury report, the San Francisco 49ers announced that left tackle Trent Williams will miss ...

After Sunday's matchup with the 49ers, Buffalo heads out to Los Angeles for a battle with the Rams before a showdown with the ...

The Bills are 9-2, their best start since 1992, and with a win would clinch their fifth straight AFC East title.

The Bills welcome the 49ers to upstate New York on Sunday Night Football in Week 13. Buffalo (9-2) continues its quest to ...

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.