San Francisco is in desperation mode after back-to-back losses and find itself as a touchdown underdog in Buffalo.

Snow has blanketed Orchard Park, New York, where the Buffalo Bills will play the San Francisco 49ers on Sunday Night Football ...

Four NFL games on Thanksgiving and Black Friday kicked off Week 13 action, and the full schedule continues on Sunday, Dec. 1, ...

One of the best receivers in the league will be on display when George Kittle and the San Francisco 49ers visit the Buffalo ...

The San Francisco 49ers saw their playoff chances plummet following consecutive losses to the Seattle Seahawks and Green Bay ...

Coming into the 2024 NFL season, it wouldn't have been out of the ordinary to find a Super Bowl prediction featuring the ...

Purdy is officially listed as questionable for the game, though coach Kyle Shanahan said the plan is for him to start on ...

"Sunday Night Football" in Week 13 sees the San Francisco 49ers taking on the Buffalo Bills. Here's the latest on a snowy ...

The #Bills have activated Pro Bowl LB Matt Milano off Injured Reserve and he’ll play on Sunday against the #49ers for the ...

Ten months after their wild-card playoff game against the Pittsburgh Steelers was postponed due to blizzard conditions, the ...

The Buffalo Bills have reactivated All-Pro linebacker Matt Milano ahead of their Week 13 match up against the San Francisco ...

It must be holiday season when the Buffalo Bills are asking fans to help clear snow at the team’s Highmark Stadium.