The NFL and the league’s players’ union agreed to modify their substance abuse policy, increasing the THC level for a positive test, according to a memo that was sent to agents and players on ...

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

Christian McCaffrey on Wednesday shared his first message to his fans after suffering a season-ending injury on Sunday.

Having suffered a knee injury that landed him on injured reserve during a snowy loss to the Bills on Sunday night, 49ers ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...

San Francisco 49ers running back Christian McCaffrey scared NFL fans across the country this Wednesday with a heartfelt ...

Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

McCaffrey appeared to have finally gotten untracked against ... and Guerendo became the lead runner for a team that is sixth ...

Christian McCaffrey suffered a torn PCL in the San Francisco 49ers' 35-10 Week 13 loss to the Buffalo Bills. The injury is ...