The San Francisco 49ers look ready to make Brock Purdy their QB of the future, but they may need to act fast to get it done ...

RB Christian McCaffrey, playing in just his fourth game since returning from Achilles tendinitis, suffered a PCL injury ...

It’s been a rough day – and a rough season - for 49ers fans. Many are depressed over a brutal loss Monday night in Buffalo ...

Al-Shaair has issued a furious response to criticism of his brutal tackle on Trevor Lawrence, claiming he's being racially ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

Here are the full game day inactive lists for both the Buffalo Bills and San Francisco 49ers ahead of their Week 13 matchup ...

Buffalo’s grounds crew has made an effort to clear the field. They had a tarp on that has now been removed, and they’ve ...

We could be looking at a Winter Wonderland in Buffalo when the Bills host the 49ers in a December affair with playoff ...

Meanwhile, the 5-6 49ers are dealing with massive injury struggles. All-Pro left tackle Trent Williams, Defensive Player of ...

Neil Reynolds, Jeff Reinebold and Phoebe Schecter discuss San Franciscos playoff prospects on the Inside The Huddle Podcast; ...

Purdy is officially listed as questionable for the game, though coach Kyle Shanahan said the plan is for him to start on ...

San Francisco 49ers TE George Kittle, LB Fred Warner and QB Brock Purdy outlined the team's performance on "SNF" against the Buffalo Bills.